QT dispersion was significantly reduced 1 month after surgery and the dispersion was further diminished 2 years later - significant change after sympathectomy

The HRV analysis showed a significant change of indices reflecting sympatho-vagal balance indicating significantly reduced sympathetic (LF) and increased vagal (HF, rMSSD) tone. These changes still persisted after 2 years. Global HRV increased over time with significant elevation of SDANN after 2 years. QT dispersion was significantly reduced 1 month after surgery and the dispersion was further diminished 2 years later.

http://www.sciencedirect.com/science/article/pii/S0167527399001011

Functional and organic vascular wall changes after sympathectomy and partial nerve damage

Langenbecks  

Arch  

Klin  

Chir  

Ver  

Dtsch  

Z  

Chir.  

1959;;291:217-31. 

sympathectomy and parasympathectomy lead to hyperfunction of the serotoninergic system and pathology

We studied the balance of activity of sympathetic, parasympathetic, and serotoninergic divisions of the autonomic nervous system in the regulation of the heart function in rabbits. High activities of the sympathetic and parasympathetic system are associated with antagonistic interactions between them. Moderation of activity of these systems could be accompanied by activation of the serotoninergic system. Physiological sympathectomy and parasympathectomy lead to hyperfunction of the serotoninergic system and pathology. 

Bulletin of Experimental Biology and Medicine, Vol. 140, No. 5, 2005 PHYSIOLOGY

Decrease in basal heart rate, norepinephrine level after sympathectomy

Endoscopic thoracic sympathectomy – its effect in the treatment of refractory angina pectoris

Interact CardioVasc Thorac Surg (2006) 5 (4): 464-468. 

Martin Striteskya, Milos Dobiasa, Rudolf Demesb, Michal Semradc,*, Eva Poliachovaa, Tomas Cermaka, Jiri Charvatd and Ivan Maleke
Author Affiliations
*Corresponding author. Tel.: +420224962781; fax: +420224922695. E-‐‑mail address:

+

↵

semradvfn@hotmail.com (M. Semrad).
Abstract

Received September 16, 2005. Revision received February 12, 2006. Accepted March 13, 2006.

Objective: To document an improvement in the quality of life in a group of patients with refractory angina and videothoracoscopic sympathectomy (VTSY) during the early postoperative period and a six-‐‑month follow-‐‑up. Methods: Ten patients with angina CCS IV refractory to a conventional therapy underwent VTSY between the years 1998 and 2002 at our institution. All patients underwent a complex preoperative evaluation, including pain assessment using a visual analog scale (VAS). Proximal thoracic sympathetic blockage was performed in all patients as a diagnostic test. The resection of bilateral Th2-‐‑Th4 ganglions was performed under general anesthesia and selective lung ventilation. All patients were monitored 6 months after the VTSY. Results: No deaths occurred in our group of patients, with an average hospital stay of
4.1 days. Nine of the ten operated patients referred an important subjective relief of pain. There was a drop from 10 to 4 according to VAS (P<0.05), and from 4 to 2.4 according to CCS (P<0.05). Decreases in basal heart rate, norepinephrine level, and an occurrence of ventricular premature beats reached the level of statistical significance. Conclusions: The increasing number of patients with refractory angina prompted a search for an effective and safe therapy to improve the quality of their life. New evidence in the pathophysiology of an ischemic myocardium and investigation of the impact of thoracic sympathectomy suggests sympathetic denervation seems to be a possible alternative method for the treatment of refractory angina pectoris. 

Long-term effect of endoscopic transthoracic s... [Int J Cardiol. 1999] - PubMed - NCBI

Long-term effect of endoscopic transthoracic s... [Int J Cardiol. 1999] - PubMed - NCBI: "We evaluated short and long-term effects on QT dispersion and autonomic balance after endoscopic transthoracic sympathicotomy (ETS). Heart rate variability (HRV) reflects autonomic balance of the heart. QT dispersion is a marker of cardiac electrical instability in patients with ischemic heart disease. Holter recordings for 24 h and a twelve-lead ECG were made prior to, 1 month, 1 year and 2 years after ETS. HRV was analysed in time domain and spectral analysis was performed during controlled respiration in supine position and during head up tilt. Dispersion of QT time and QTc were calculated. Of 88 patients, 62 (60) were eligible for HRV (QT-dispersion) analysis after 1 month, 39 (38) patients after 1 year and 23 (24) patients after 2 years. The HRV analysis showed a significant change of indices reflecting sympatho-vagal balance indicating significantly reduced sympathetic (LF) and increased vagal (HF, rMSSD) tone. These changes still persisted after 2 years. Global HRV increased over time with significant elevation of SDANN after 2 years. QT dispersion was significantly reduced 1 month after surgery and the dispersion was further diminished 2 years later."

lowering of heart rate and blood pressure, decreased responsiveness of the cardiocirculatory system to emotional stimuli after sympathectomy

"lowering of heart rate and blood pressure, decreased responsiveness of the cardiocirculatory system to emotional stimuli: it is an effect that is especially noticeable in patients operated on for erythrophobia and less evident in those operated for hyperhidrosis. It is almost always a welcome phenomenon, which contributes considerably to the feeling of tranquility and serenity that generally supersedes anxiety. Excessive reduction in blood pressure or heart rate may lead to a state of weakness and fatigue that may require removal of the clips in approx. 2%. This rare state of asthenia contrasts with the increased energy and vigor that most patients experience when they feel freed from overwhelming anxiety."    

"The neurovegetative nervous system is, however, very dynamic and tends to adapt continuously during lifetime to all environmental or organic changes and conditions. Therefore, it reacts very individually when a reflex circuit has been blocked. The resulting side effects cannot be predicted in detail, and though they in most patients are relatively mild or even absent, there is a small group of patients developing heavy side effects. Therefore, surgery should only be considered in carefully selected cases in whom non-invasive treatment has failed and in whom the detrimental consequences of erythrophobia regarding the psychosocial situation and the quality of life is such to justify more adverse side effects. It should also always be kept in mind that therapy can be ineffective and that, in the long term, 10-15% of patients do not consider themselves satisfied with the result of surgery. In any case, the author prefers the use of a potentially reversible surgical technique (ESB), instead of destructive techniques (cutting, coagulation, removal of ganglia)."  

http://www.chir.it/en_erythrophobia.php

prolongation of the isometric (tension) period (TP) of the left ventricle occurred in the majority (72 per cent) of all cases after sympathectomy

The prolongation of the isometric (tension) period (TP) of the left ventricle which occurred in the majority (72 per cent) of all cases after unilateral or bilateral transthoracic sympathectomy (without or with unilateral or bilateral transthoracic splanchnicotomy) indicates a diminution of inotropic cardiac action. It can be assumed to correspond to the cholinergic (vagal) preponderance which results from a partial or complete sympathetic denervation of the heart. Reduction of the pulse pressure occurred in 56 per cent of the cases, probably due to the same mechanism.

www.chestjournal.org/content/38/4/423.full.pdfby W RAAB - 1960

significant associations between heart rate and regional cerebral blood flow

Neurosci Biobehav Rev. 2012 Feb;36(2):747-56. doi: 10.1016/j.neubiorev.2011.11.009. Epub 2011 Dec 8.

A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health.

The intimate connection between the brain and the heart was enunciated by Claude Bernard over 150 years ago. In our neurovisceral integration model we have tried to build on this pioneering work. In the present paper we further elaborate our model and update it with recent results. Specifically, we performed a meta-analysis of recent neuroimaging studies on the relationship between heart rate variability and regional cerebral blood flow. We identified a number of regions, including the amygdala and ventromedial prefrontal cortex, in which significant associations across studies were found. We further propose that the default response to uncertainty is the threat response and may be related to the well known negativity bias. Heart rate variability may provide an index of how strongly 'top-down' appraisals, mediated by cortical-subcortical pathways, shape brainstem activity and autonomic responses in the body. If the default response to uncertainty is the threat response, as we propose here, contextual information represented in 'appraisal' systems may be necessary to overcome this bias during daily life. Thus, HRV may serve as a proxy for 'vertical integration' of the brain mechanisms that guide flexible control over behavior with peripheral physiology, and as such provides an important window into understanding stress and health.

http://www.ncbi.nlm.nih.gov/pubmed/22178086

CARDIOVASCULAR CHANGES POST SYMPATHECTOMY

Short- and Long-term Effects

Pulse rates taken at rest and after effort were significantly
lower than those taken after operation, and the blood pressure
response to exercise was blunted. ECG tracings showed a sig-
nificant change in the electrical frontal plane axis and shortening
of the QTc interval.


Tel-Hashomer, and Tel Aviv University Sackler Medical
School, Tel Aviv, Israel, and the National Heart,
Lung, Blood Institute, National Institutes of Health,t Bethesda, Maryland

Heart Rate Variability before and after the Endoscopic Transthoracic Sympathectomy in Hyperhidrosis

The etiology of primary hyperhidrosis has been speculated as "unknown" hyperactivity of the sympathetic nervous system. In our clinic, we performed endoscopic transthoracic sympathectomy(ETS) for the treatment of hyperhidrosis. In this study, we studied the cardiac autonomic nervous function using heart rate variability(HRV) before and after ETS in 70 patients with hyperhidrosis, and compared with normal control. Before ETS, high frequency(HF) power was lower in hyperhidrosis than control group, however, there was no significant difference in LF/HF. After ETS, LF/HF decreased by 31%, and lower than control. No Severe cpomplications were occurred by ETS. In conclusion, on the cardiac autonomic nervous tone, hyperhidrosis patients had the relative dominance of the sympathetic nervous tone by suppression of the parasympathetic nervous tone. After ETS, the sympathetic nervous tone was suppressed.

http://sciencelinks.jp/j-east/article/200002/000020000299A0930354.php

Heart Rate Variability before and after the Endoscopic Transthoracic Sympathectomy in Hyperhidrosis.
Accession number;99A0930354
Title;Heart Rate Variability before and after the Endoscopic Transthoracic Sympathectomy in Hyperhidrosis.
Author; YOSHIDA K (Saga Medical School) UTSUNOMIYA T (Saga Medical School) HIRATA M (Saga Medical School) MOROOKA T (Saga Medical School) MATSUO A (Saga Medical School) SHIRAHAMA K (Saga Medical School) TANAKA M (Saga Medical School) HARANO K (Saga Medical School) MATSUO S (Saga Medical School)
Journal Title;Ther Res
Journal Code:Y0681A
ISSN:0289-8020 VOL.20;NO.9;PAGE.2630-2634(1999) Figure&Table&Reference;FIG.2, REF.19 Pub. Country;Japan
Language;English 

HRV is a direct predictor of cardiovascular risk and all-cause mortality (TaskForce 1996)

Heart rate variability (HRV) is of increasing interest because it is a marker of cardiovascular autonomic function and because reduced HRV is a direct predictor of cardiovascular risk and all-cause mortality (TaskForce 1996). While they do not provide direct measures of autonomic activity, indices from HRV are widely recognized as useful and powerful indicators of the relationship between psychological and physiological processes (Berntson et al. 1997; Pagani et al. 1997; TaskForce 1996).



HRV can be evaluated by time and frequency domain indices, reflecting the activity of the autonomic nervous system. Among the most used indices, the standard deviation of normal beatto-beat (R–R) intervals

(SDNN) has been suggested to reflect global variability, while the root-mean-square of successive R–R (RMSSD) and high frequency (HF) power have been linked to vagal activity (TaskForce 1996). Although more controversial, low frequency (LF) power is thought to reflect sympathetic activity with a parasympathetic component (Berntson et al.1997; Pomeranz et al. 1985; but see Pagani et al. 1997).

http://cerca.labo.univ-poitiers.fr/IMG/pdf_EJAP10-AlbinetColl.pdf

important relationship among cognitive performance, HRV, and prefrontal neural function

Heart rate variability, prefrontal neural func... [Ann Behav Med. 2009] - PubMed - NCBI: "These findings in total suggest an important relationship among cognitive performance, HRV, and prefrontal neural function that has important implications for both physical and mental health. Future studies are needed to determine exactly which executive functions are associated with individual differences in HRV in a wider range of situations and populations."

http://www.ncbi.nlm.nih.gov/pubmed/19424767

Reduced HRV is significantly associated with lower cognitive performance

http://www.ncbi.nlm.nih.gov/pubmed/24077752

cardiovascular adjustment to exercise and sympathectomy

Mean arterial pressure and total peripheral resistance were significantly reduced at rest and during steady state of exercise as compared to controls prior to sympathectomy identical vO₂, whereas CO remained unchanged.

The significant fall in left circumflex coronary flow was proportional to the decline in external heart work due to sympathectomy both at rest and under exercise.

http://www.springerlink.com/content/k2n6j4555g16x773/

Sympathectomy altered electroactivity on the heart

The influences on the cardiac autonomic nerve system of the ETS of upper thoracic sympathetic nerve were seen to be of a lesser degree at rest. However, the response to sympathetic stimulation was suppressed after the surgery.

Eur J Cardiothorac Surg 1999;15:194-198

http://ejcts.ctsnetjournals.org/cgi/content/full/15/2/194

dennervation sensitization increases the arrhythmia susceptibility

The NA content in the heart was not measured but it is likely to be small at least at the 10-day period. It is known that three days after chemical sympathectomy NA content is only 7% of normal value [6]. Second, the development of adrenoceptor supersensitivity in the transplanted heart was demonstrated clearly with enhanced heart rate responses to NA or propranolol (at Day 10) [1]. As dennervation sensitization increases the arrhythmia susceptibility [6], it is thus possible that, in the presence of receptor supersensitivity, adrenergic activation occurs by either increase in circulating catecholamines and possibly local release of residual NA, which might still have been sufficient to contribute to arrhythmia development.
Role of sympathoadrenergic mechanisms in arrhythmogenesis
Xiao-Jun Du* and Anthony M. Dart
Baker Medical Research Institute, Melbourne, Victoria, Australia 
Cardiovascular Research 1999 43(4):832-834;

A 54-year-old woman developed possible heart failure while receiving pregabalin for intercostal neuralgia after sympathectomy

Anonymous. Reactions Weekly 1392 (Mar 10, 2012): 39.

A 54-year-old woman developed possible heart failure while receiving pregabalin [route not stated] for intercostal neuralgia.

The woman, who had a history of bilateral thoracic sympathectomy, started treatment with pregabalin 150 mg/day for the first week, followed by 300 mg/day in the second week. Tramadol was also administered. During follow-up on day 17 of treatment, she reported a 3-day history of swelling in her hands and ankles. Pretibial oedema was evident on examination and she was admitted for side-effect follow-up and pain palliation. 

During follow-up, a thorax CT scan revealed cardiomegalia, the presence of pericardial fluid, and pleural fluid at the base of both hemithorax, more significantly on the right side.

Diuretic therapy was initiated and, on day 3 of treatment, echocardiography showed an ejection fraction of 76%. A follow-up thorax CT scan, performed 15 days after discontinuing pregabalin, revealed disappearance of the cardiomegalia and pericardial fluid, with only minimal pleural effusion. The woman's peripheral oedema and dyspnoea had also subsided. Following reports of reduced but persistent pain, gabapentin 300 mg/day was initiated, followed by a dosage increase to 900 mg/day. 

References

1. Erdogan G, Ceyhan D, Gulec S.Possible heart failure associated with pregabalin use: case report. Agri 23: 80-3, No. 2, Apr 2011 - Turkey.

Thoracoscopic sympathectomy increases efferent cardiac vagal activity and baroreceptor sensitivity

Thoracoscopic sympathectomy at levels T2 or T2-T3 is a treatment for focal hyperhidrosis and facial blushing. These levels of the sympathetic trunk innervate the heart, and consequently, the procedure is reported to change the heart rate variability due to changes in efferent cardiac autonomic activity. Our objective was to investigate the effects of thoracoscopic sympathectomy on global autonomic control, including baroreceptor sensitivity.

Eight patients (6 F, median age 28 years [range 20-58 years]) were exposed to the tilt-table test and cardiopulmonary exercise test before, and 3 months after, thoracoscopic sympathectomy. Eight healthy age-, gender- and BMI-matched controls were used as controls and underwent the same tests once. During tilt-table testing electrocardiogram, blood pressure, impedance cardiography and respiration were measured continuously, and efferent cardiac autonomic balance was estimated.

RESULTS:

The heart rate measured during orthostatic stress test was lowered after thoracoscopic sympathectomy (between-group; P = 0.01) due to a change in autonomic tone, with increased vagal (high-frequency power n.u.; P = 0.001), and reduced sympathetic efferent cardiac activity (low-frequency power n.u.; P < 0.001). Baroreceptor sensitivity measured during rest was increased (26 ± 13 vs 44 ± 19 ms/mmHg; P = 0.01), and diastolic blood pressure reduced after surgery (P = 0.01).

http://www.ncbi.nlm.nih.gov/pubmed/23847183

SYMPATHECTOMY FOR ANGINA

Hirakawa, Naomi; Ogawa, Ikuyo; Yoshida, Kazuyo; Totoki, Tadahide

Institution
Anesthesiology and Critical Care Medicine, Cardiology, Saga Medical School, Saga, Saga, Japan.
Title
Effects of Endoscopic Thoracic Sympathectomy (ETS) for the Treatment of Patients with Intractable Vasospastic Angina. #151; Changes in Autonomic Nervous Activity and Symptomatic Change after ETS in Patients with Intractable Vasospastic Angina #151;.[Miscellaneous]
Source
ASA Annual Meeting Abstracts. LOCAL ANESTHESIA AND PAIN. 99(3A):A998, October 2003.